WebSep 3, 1991 · After a preliminary dose-finding study involving 12 patients with advanced or locally recurrent head and neck cancer, 27 patients were treated on a phase II protocol, using fluorouracil 350 mg/m2/d by continuous intravenous (IV) infusion over 5 days, followed on the sixth day by a 2-hour IV infusion of cisplatin 50 mg/m2, administered … WebIn 18 patients receiving 5-FU plus cisplatin with radiation doses of 54-55 Gy, actuarial local control was 85% at 2 years. Fifteen patients failed chemoXRT, 13 of whom had abdominoperineal resection for salvage; the overall local control rate was 93% (54/58). The actuarial survival at 5 years was 81% for the 5-FU chemoXRT group and 94% at 2 ...
Cisplatin and 5-fluorouracil in the primary management of ... - PubMed
WebIn contrast, patients receiving radiotherapy with concurrent cisplatin had chemotherapy-related toxic effects (e.g., neutropenia and nausea or vomiting) and increased rates of severe radiation ... WebMar 1, 2024 · The global incidence of squamous cell carcinoma of the head and neck (SCCHN) is estimated at more than 700,000 cases newly diagnosed annually. 1 A majority of patients present with locally advanced SCCHN (LA-SCCHN), and surgery is a mainstay of treatment for resectable cases. Postoperative chemoradiotherapy with 3-weekly … dvd 1981 wembly military tattoo
Anal Cancer Treatment (PDQ®)–Health Professional Version
WebSep 15, 2024 · Replacement of mitomycin by cisplatin Capecitabine as an alternative to infusional fluorouracil Radiation therapy dose and schedule Special populations - Patients living with HIV - Patients with locally advanced disease - Patients with para-aortic nodal involvement - Elderly or extensive comorbidity - Local excision for small T1 tumors … WebFeb 27, 2024 · A prospective randomized trial of methotrexate versus cisplatin in the treatment of recurrent squamous cell carcinoma of the head and neck. Cancer 1983; 52:206. A phase III randomised trial of cistplatinum, methotrextate, cisplatinum + methotrexate and cisplatinum + 5-FU in end stage squamous carcinoma of the head and neck. WebDoctors give a lot of intravenous (IV) fluid with cisplatin to help prevent this. 5-fluorouracil (5-FU) and capecitabine can cause sores in the mouth (mucositis) that can make it hard to eat. These drugs can also cause diarrhea. Ifosfamide can damage the lining of the bladder (hemorrhagic cystitis). dvd 13th floor